FDA approves new over-the-counter gel for erectile dysfunction
36Bnyan, R.; Khan, I.; Ehtezazi, T.; Saleem, I.; Gordon, S.; O’Neill, F.; Roberts, M. Surfactant Effects on Lipid-Based Vesicles Properties. 2018, 107, 1237– 1246, DOI: 10.1016/j.xphs.2018.01.005Google Scholar36Surfactant effects on lipid-based vesicles propertiesBnyan, Ruba; Khan, Iftikhar; Ehtezazi, Touraj; Saleem, Imran; Gordon, Sarah; O'Neill, Francis; Roberts, MatthewJournal of Pharmaceutical Sciences (Philadelphia, PA, United States) (2018), 107 (5), 1237-1246CODEN: JPMSAE; ISSN:0022-3549. Understanding the effect of surfactant properties is crit. This review evaluates previous studies to explain the influence of surfactant properties on the behavior of lipid vesicular systems, specifically their size, charge, stability, entrapment efficiency, pharmacokinetics, and pharmacodynamics.
- The gel allows easier dose adjustment compared to fixed-dose tablets.
- Some patients prefer the non-invasive nature of gel application.
- Patient counseling addresses realistic expectations from topical sildenafil.
- Use on damaged skin should be strictly avoided to prevent systemic absorption spikes.
- Can be incorporated into broader male sexual health management.
- Clinical effectiveness depends on consistent and correct application.
- Discreet packaging aids in user privacy and compliance.
Generally, the size of vesicles decreases by increasing the surfactant concn., carbon chain length, the hydrophilicity of the surfactant head group, and the hydrophilic-lipophilic balance. can also lead to an increase in charge, which in turn reduces vesicle aggregation and enhances the stability of the system. The vesicles' entrapment efficiency not only depends on the surfactant properties but also on the encapsulated drug. For example, the encapsulation of a lipophilic drug could be enhanced by using a surfactant with a low hydrophilic-lipophilic balance value.
- Dermatological testing ensures sildenafil gel safety on human skin.
- Some formulations include penetration enhancers like DMSO.
- The gel formulation may reduce gastrointestinal side effects seen in pills.
- Stability testing confirms product shelf life.
- Secondary packaging often includes detailed usage instructions.
- Gel use can be part of a comprehensive ED treatment plan.
- Patients should keep a symptom diary to evaluate treatment efficacy.
Moreover, the membrane permeability of vesicles depends on the surfactant's carbon chain length and transition temp. In addn., surfactants have a clear influence on pharmacokinetics and pharmacodynamics such as sustaining drug release, enhancing the circulation time of vesicles, improving targeting and cellular uptake. A.; Abd-Elsalam, W.
What is Vega Oral Jelly?
A. Transdermal Delivery of Ondansetron Hydrochloride via Bilosomal Systems: In Vitro, Ex Vivo, and In Vivo Characterization Studies. AAPS PharmSciTech 2018, 19, 2276– 2287, DOI: 10.1208/s12249-018-1019-yGoogle ScholarThere is no corresponding record for this reference. A. Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurements.
Does sildenafil interact with other medicines (drug interactions)?
2001, 217, 13– 24, DOI: 10.1016/S0378-5173(01)00576-2Google Scholar33Elasticity of vesicles assessed by electron spin resonance, electron microscopy and extrusion measurementsvan den Bergh, B. Fatty acid spin labels were incorporated into vesicles, composed of the single chain non-ionic surfactant octaoxyethylenelaurate-ester (PEG-8-L), the sucrose laurate-ester L-595 and cholesterol sulfate (CS) to monitor local dynamic properties of lipid mols. in vesicle bilayers and to study the elasticity of vesicle bilayers. Studies with the spin label probes 5-, 12- and 16-doxyl stearic acid (DSA) indicated that both the order parameter and the rotational correlation times increased when the doxyl group was positioned closer to the headgroup region. These findings indicate that the fluidity of membranes decreased near the headgroup region.
Missed Dose
Comparing 16-DSA incorporated in vesicle formulations with either 30 or 70 mol% showed no difference in alkyl chain mobility as was reflected by the order parameter. The rotational correlation times, however, showed a slowdown from 0.38 to 0.71 and 1.13 ns when the PEG-8-L molar content was decreased from 100 to 70 and 30 mol% for PEG-8-L:L-595:CS vesicles, resp. Extrusion measurements indicated an increase in elasticity of vesicle bilayers as the molar content of PEG-8-L was increased from 10 to 90 mol%. Incorporation of cholesterol sulfate stabilizes vesicles and thereby, decreases the elasticity. The increased elasticity correlated excellent with a redn. H.; Al-Mahallawi, A. M.
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Fabrication of novel ultradeformable bilosomes for enhanced ocular delivery of terconazole: In vitro characterization, ex vivo permeation and in vivo safety assessment. 2016, 513, 688– 696, DOI: 10.1016/j.ijpharm.2016.10.006Google ScholarThere is no corresponding record for this reference. 38Mahmoud, T. M.; Nafady, M. M.; Farouk, H. O.; Mahmoud, D. M.; Ahmed, Y. M.; Zaki, R. M.; Hamad, D. S. Novel Bile Salt Stabilized Vesicles-Mediated Effective Topical Delivery of Diclofenac Sodium: A New Therapeutic Approach for Pain and Inflammation.
1. Introduction
Bilosomes in the context of oral immunization: development, challenges and opportunities. Drug Discov Today 2016, 21, 888– 899, DOI: 10.1016/j.drudis.2016.03.013Google ScholarThere is no corresponding record for this reference. 30Khafagy, E. S.; Almutairy, B. K.; Abu Lila, A.
2.10. In Vivo Studies
S. Tailoring of Novel Bile Salt Stabilized Vesicles for Enhanced Transdermal Delivery of Simvastatin: A New Therapeutic Approach against Inflammation. Polymers (Basel) 2023, 15, 677, DOI: 10.3390/polym15030677Google ScholarThere is no corresponding record for this reference. 31Aldawsari, M. F.; Khafagy, E.
Does sildenafil interact with foods or drinks?
S.; Alotaibi, H. F.; Abu Lila, A. S. Vardenafil-Loaded Bilosomal Mucoadhesive Sponge for Buccal Delivery: Optimization, Characterization, and In Vivo Evaluation. Polymers (Basel) 2022, 14, 4184, DOI: 10.3390/polym14194184Google ScholarThere is no corresponding record for this reference. In Pharmaceuticals 2022, 15, 1106, DOI: 10.3390/ph15091106Google ScholarThere is no corresponding record for this reference. 39Zafar, A.; Alruwaili, N. K.; Imam, S. S.; Hadal Alotaibi, N.; Alharbi, K. S.; Afzal, M.; Ali, R.; Alshehri, S.; Alzarea, S. I.; Elmowafy, M. Bioactive Apigenin loaded oral nano bilosomes: Formulation optimization to preclinical assessment. 2021, 29, 269– 279, DOI: 10.1016/j.jsps.2021.02.003Google ScholarThere is no corresponding record for this reference.
- Different brands may vary in sildenafil concentration and gel consistency.
- Patient adherence to application timing directly affects treatment outcomes.
- Combining sildenafil gel with counseling can improve overall sexual health.
- Hydration of the skin before application may improve absorption.
- Avoiding excessive amounts prevents overdosing and related side effects.
- Proper disposal methods for used applicators protect environment and privacy.
- Sildenafil gel is part of a broader approach including lifestyle changes for ED.
40Duangjit, S.; Pamornpathomkul, B.; Opanasopit, P.; Rojanarata, T.; Obata, Y.; Takayama, K.; Ngawhirunpat, T. Role of the charge, carbon chain length, and content of surfactant on the skin penetration of meloxicam-loaded liposomes. J. Nanomedicine 2014, 9, 2005– 2017, DOI: 10.2147/IJN.S60674Google ScholarThere is no corresponding record for this reference. 41Trotta, M.; Peira, E.; Debernardi, F.; Gallarate, M. Elastic liposomes for skin delivery of dipotassium glycyrrhizinate. (Elsevier Science B.V.)The aim of this study was to evaluate the sildenafil 20 mg prescription possibility of using liposomes for skin delivery of sildenafil 25 mg tablets dipotassium glycyrrhizinate (KG), an anti-inflammatory agent employed in treating acute and chronic dermatitis, and of formulating such liposomes in an oil-in-water emulsion (O/W).
Side Effects
In conclusion, these results demonstrate that when the molar content of the single chain non-ionic surfactant PEG-8-L in vesicles is increased the elasticity is enhanced and the rotational correlation time is reduced. The enhanced elasticity might contribute to an optimal design of vesicles as drug carriers for transdermal application. 34Abdallah, M. H.; Lila, A. S.
Other Interactions
A.; Unissa, R.; Elsewedy, H. S.; Elghamry, H. A.; Soliman, M. S. Brucine-Loaded Ethosomal Gel: Design, Optimization, and Anti-inflammatory Activity.
2.2. Fabrication of SDF-Loaded Bilosomes
AAPS PharmSciTech 2021, 22, 269, DOI: 10.1208/s12249-021-02113-8Google ScholarThere is no corresponding record for this reference. A.; Aburahma, M. H. Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicam. 2015, 485, 329– 340, DOI: 10.1016/j.ijpharm.2015.03.033Google Scholar35Investigating the potential of employing bilosomes as a novel vesicular carrier for transdermal delivery of tenoxicamAl-Mahallawi, Abdulaziz M.; Abdelbary, Aly A.; Aburahma, Mona H.International Journal of Pharmaceutics (Amsterdam, Netherlands) (2015), 485 (1-2), 329-340CODEN: IJPHDE; ISSN:0378-5173. KG had emulsifying properties and the possibility of producing elastic liposomes was verified. soya lecithin (PC) or hydrogenated soya lecithin (HPC) mixed with KG in wt./wt. method and then passed through a high pressure homogenizer. Liposome size and entrapment efficiency were detd. and the interaction between KG and HPC was investigated using differential scanning calorimetry. Transepidermal permeation through intact pig skin and skin deposition of KG from liposomes and O/W emulsion contg. liposomes were assessed and compared with values for aq. Liposome sizes ranged from 90 to 120 nm. Entrapment efficiency depended on the lipid:KG ratio; the max. efficiency was obtained at 4:1 wt./wt. KG interacted with liposomes disrupting and fluidizing the lipid bilayer, forming elastic liposomes able to penetrate through membrane pores of diam. The liposome structure was maintained when dispersed in an O/W emulsion. The skin fluxes were less than the HPLC detection limit for all systems, while skin deposition increased 4.5-fold compared with aq.
Frequently Asked Questions
(Elsevier B.V.)Bilosomes represent an evolving vesicular carrier that have been explored for oral vaccines delivery based on its ability to resist enzymes and bile salts in the gastrointestinal tract (GIT). Bilosomes vesicles are formed of bilayer membrane of non-ionic surfactant mols. Although, bilosomes have not been proposed for transdermal drug delivery, this carrier seems to have promising potential in this regard. Accordingly, the aim of this investigation was to assess the capability and safety of utilizing bilosomes for transdermal delivery of tenoxicam (TX) as a model drug. A 3122 full factorial design was adopted to study the effects of different formulation parameters on bilosomes properties and select the optimal formulation using Design-Expert software.
2.5. In Vitro Release Studies of SDF-BS
The selected formulation displayed nano-sized spherical vesicles (242.5 ± 6.43 nm) with reasonable entrapment efficiency percent (68.33 ± 2.33%). Confocal laser scanning microscopy confirmed the capability of the flourolabeled bilosomes to penetrate deep within the skin. Both, ex vivo permeation and in vivo skin deposition studies confirmed the superiority of bilosomes over drug soln. study proved the safety of topically applied bilosomes. In summary, the highlighted results confirmed that bilosomes can be further adopted for delivering drugs transdermally. Novel Enhanced Therapeutic Efficacy of Dapoxetine HCl by Nano-Vesicle Transdermal Gel for Treatment of Carrageenan-Induced Rat Paw Edema. AAPS PharmSciTech 2020, 21, 113, DOI: 10.1208/s12249-020-01656-6Google ScholarThere is no corresponding record for this reference.
| Step | Procedure | Tips | Precautions |
|---|---|---|---|
| 1 | Clean and dry the application area | Use alcohol wipes for cleanliness | Avoid open wounds |
| 2 | Apply a small amount (about 0.5 g) evenly | Use applicator if provided | Do not overdose |
| 3 | Allow absorption for 10-15 minutes | Do not massage vigorously | Avoid bathing immediately after |
| 4 | Wash hands thoroughly afterward | Prevent inadvertent transfer to other areas | Keep out of reach of children |
